منابع مشابه
Discovering Domains Mediating Protein Interactions
Background: Protein-protein interactions do not provide any direct information regarding the domains within the proteins that mediate the interactions. The majority of proteins are multi domain proteins and the interaction between them is often defined by the pairs of their domains. Most of the former studies focus only on interacting domain pairs. However they do not consider the in...
متن کاملClassifying Permanent and Transient Protein Interactions
Currently much research is devoted to the characterization and classification of transient and permanent protein-protein interactions. From the literature, we take data sets consisting of 161 permanent (65 homodimers, 96 heterodimers) and 242 transient interactions. We collect over 300 interface attributes relating to size, physiochemical properties, interaction propensities, and secondary stru...
متن کاملTransient RNA–protein interactions in RNA folding
The RNA folding trajectory features numerous off-pathway folding traps, which represent conformations that are often equally as stable as the native functional ones. Therefore, the conversion between these off-pathway structures and the native correctly folded ones is the critical step in RNA folding. This process, referred to as RNA refolding, is slow, and is represented by a transition state ...
متن کاملdiscovering domains mediating protein interactions
background: protein-protein interactions do not provide any direct information regarding the domains within the proteins that mediate the interactions. the majority of proteins are multi domain proteins and the interaction between them is often defined by the pairs of their domains. most of the former studies focus only on interacting domain pairs. however they do not consider the interaction...
متن کاملRabies Infection: An Overview of Lyssavirus-Host Protein Interactions
Viruses are obligatory intracellular parasites that use cell proteins to take the control of the cell functions in order to accomplish their life cycle. Studying the viral-host interactions would increase our knowledge of the viral biology and mechanisms of pathogenesis. Studies on pathogenesis mechanisms of lyssaviruses, which are the causative agents of rabies, have revealed some important ho...
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ژورنال
عنوان ژورنال: Protein Engineering Design and Selection
سال: 2011
ISSN: 1741-0126,1741-0134
DOI: 10.1093/protein/gzr025